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Piperidine, 99%
Description
Chemical Properties
· Formula : C5H11N
· Formula weight : 85.15
· Melting Point : -11°
· Boiling Point : 105-106°
· Flash point : 3°(37°F)
· Density : 0.862
· Refractive Index : 1.4520
· Sensitivity : Air Sensitive. Store under Argon. Ambient temperatures.
· Form : Liquid
· Solubility : Miscible with ethanol, water,ethyl ether, acetone, benzene and chloroform
Literature References
Base catalyst in the Doebner modification of the Knoevenagel condensation; see Malonic acid, A11526.
Widely used for cleavage of Fmoc protecting groups: J. Org. Chem., 52, 1197 (1987); Tetrahedron Lett., 34, 6135 (1993). See Appendix 6.
For preparation of the piperidine enamine of cyclooctanecarboxaldehyde, and its subsequent use in the synthesis of spirohexadienones, see: Org. Synth. Coll., 7, 473 (1990).
Applications
Extensively finds applications as a base, a nucleophile and a solvent. Used for the production of dipiperidinyl dithiuram tetrasulfide, which is used as a rubber vulcanization accelerator. It is commonly used in solid phase peptide synthesis (F-MOC Chemistry) and in chemical degradation reactions (sequencing of DNA). Used in making rubber, curing epoxy resins and in fine chemicals, and pharmaceuticals.
Notes
The piperidine skeleton is present in several naturally occuring alkaloids, such as piperine, solenopsin, coniine, etc., and in a wide variety of pharmaceuticals, such as SSRI (Selective Serotonin Reuptake Inhibitors), Vasodilators, SERM (Selective Estrogen Receptor Modulators), Neuroleptics (Antipsychotics), Analeptics/Nootropics (Stimulants), etc. Piperidine is a strong organic base and reacts violently with oxidizers.
Other References:
· Beilstein : 102438
· Merck: 14,7468
· UN#: UN2401
GHS Hazard and Precautionary Statements
Hazard Statements : H225-H311-H331-H314
Highly flammable liquid and vapour.Toxic in contact with skin.Toxic if inhaled.Causes severe skin burns and eye damage.
Precautionary Statements : P210-P303+P361+P353-P305+P351+P338-P361-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Remove/Take off immediately all contaminated clothing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
위험 및 안전 코드
위험 문구 : 11-23/24-34
Highly flammable.Toxic by inhalation and in contact with skin.Causes burns.
안전 문구 : 16-26-27-45
Keep away from sources of ignition - No smoking.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Take off immediately all contaminated clothing.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
· TSCA : 예
· RTECS : TM3500000
